top of page


Selected peer review


Eyran, T., Vaisman-Mentesh, A., Taussig, D., Dror, Y., Aizik, L., Kigel, A., Rosenstein, S., Bahar, Y., Ini, D., Tur-Kaspa, R., Kournos, T., Marcoviciu, D., Dicker, D., & Wine, Y. (2022). Longitudinal kinetics of RBD+ antibodies in COVID-19 recovered patients over 14 months. PLoS pathogens, 18(6), e1010569.Pubmed


Rosenberg-Friedman, M., Kigel, A., Bahar, Y., Werbner, M., Alter, J., Yogev, Y., Dror, Y., Lubetzky, R., Dessau, M., Gal-Tanamy, M., Many, A., & Wine, Y. (2021). BNT162b2 mRNA vaccine elicited antibody response in blood and milk of breastfeeding women. Nature communications, 12(1), 6222.Pubmed

Taussig, D., & Wine, Y. (2021). When a virus lies in wait. eLife, 10, e71121.PubMed

Aizik, L., Dror, Y., Taussig, D., Barzel, A., Carmi, Y., & Wine, Y. (2021). Antibody Repertoire Analysis of Tumor-Infiltrating B Cells Reveals Distinct Signatures and Distributions Across Tissues. Frontiers in immunology, 12, 705381.Pubmed

Avram, O., Kigel, A., Vaisman-Mentesh, A., Kligsberg, S., Rosenstein, S., Dror, Y., Pupko, T., & Wine, Y. (2021). PASA: Proteomic analysis of serum antibodies web server. PLoS computational biology, 17(1), e1008607.Pubmed

Hillman, Y., Gershberg, J., Lustiger, D., Even, D., Braverman, D., Dror, Y., Ashur, I., Vernick, S., Sal-Man, N., & Wine, Y. (2021). Monoclonal Antibody-Based Biosensor for Point-of-Care Detection of Type III Secretion System Expressing Pathogens. Analytical chemistry, 93(2), 928–935. Pubmed


*Avram, O., *Vaisman-Mentesh, A., Yehezkel, D., Ashkenazy, H., Pupko, T. & Wine, Y. ASAP - A Webserver for Immunoglobulin-Sequencing Analysis Pipeline. Frontiers in Immunology 9, 1686, (2018). * first co-author. Link

Vaisman-Mentesh, A. & Wine, Y. Monitoring Phage Biopanning by Next-Generation Sequencing. Methods in molecular biology (Clifton, N.J.) 1701, 463-473, (2018). Link.


Lavinder, J.J., Hon Hoi, K., Reddy, S.T., Wine, Y., Georgiou, G. (2014). Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin Repertoire. PloS one. 9, e101322. Link

*Boutz, D.R., *Horton, A.P., *Wine, Y., Lavinder, J.J, Georgiou, G., Marcotte, E.M. (2014). Proteomic Identification of Monoclonal Antibodies from Serum. Analytical Chemistry. 86, 4758-4766.  * first co-author. Link

*Lavinder, J.J., *Wine, Y., Giesecke, C.,  Ippolito, G.C., Horton, A.P, Lungu, O.I., Hon Hoi, K., DeKosky, B.J., Murrin, E.M., Wirth, M.M., Ellington, A.D., Dörner, T., Marcotte, E.M., Boutz, D.R., Georgiou, G. (2014). Identification, Dynamics, and Functionality of the Constituent Antibodies within Human Serum after Vaccination. Proceedings of the National Academy of Sciences of the United States of America. 111, 2259-2264. * first co-author. Pubmed


*Wine, Y., *Boutz, D.R., *Lavinder, J.J., Miklos, A.E., Hughes, R.A., Hoi, K.H., Jung, S.T., Horton, A.P., Murrin, E.M., Ellington, A.D., Marcotte, E.M. & Georgiou, G.  (2013). Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response. Proceedings of the National Academy of Sciences of the United States of America 110, 2993-2998.  * first co-author. Pubmed

Cotham, V.C., Wine, Y.,  Brodbelt, J.S.  (2013). Selective 351 nm Photodissociation of Cysteine-Containing Peptides for Discrimination of Antigen-Binding Regions of IgG Fragments in Bottom-Up Liquid Chromatography - Tandem Mass Spectrometry Workflows. Analytical Chemistry 85, 5577-5585. Pubmed

DeKosky, B.J., Ippolito, G.C., Deschner, R.P., Lavinder, J.J., Wine, Y., Rawlings, B.M., Varadarajan, N., Giesecke, C., Dorner, T., Andrews, S.F., Wilson, P.C., Hunicke-Smith, S.P., Willson, C.G., Ellington, A.D. & Georgiou, G.  (2013). High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nature Biotechnology 31, 166-169.  Pubmed


Saggy, I., Wine, Y., Shefet-Carasso, L., Nahary, L., Georgiou, G. & Benhar, I.  (2012). Antibody isolation from immunized animals: comparison of phage display and antibody discovery via V gene repertoire mining. Protein Engineering Design and Selection 25, 539-549. Pubmed


Cohen-Hadar, N., Lagziel-Simis, S., Wine, Y., Frolow, F. & Freeman, A.  (2011). Re-structuring protein crystals porosity for biotemplating by chemical modification of lysine residues. Biotechnology and Bioengineering 108, 1-11. Pubmed


Wine, Y., Cohen-Hadar, N., Lamed, R., Freeman, A. & Frolow, F.  (2009). Modification of Protein Crystal Packing by Systematic Mutations of Surface Residues: Implications on Biotemplating and Crystal Porosity. Biotechnology and Bioengineering 104, 444-457. Pubmed

Cohen-Hadar, N., Wine, Y., Lagziel-Simis, S., Moscovich-Dagan, H., Dror, Y., Frolow, F. & Freeman, A.  (2009). Protein Crystal-Mediated Biotemplating. Journal of Porous Media 12, 213-220. Pubmed


Wine, Y., Cohen-Hadar, N., Freeman, A. & Frolow, F.  (2007). Elucidation of the mechanism and end products of glutaraldehyde crosslinking reaction by X-ray structure analysis. Biotechnology and Bioengineering 98, 711-718. Pubmed


Cohen-Hadar, N., Wine, Y., Nachliel, E., Huppert, D., Gutman, M., Frolow, F., Freeman, A. (2006).  Monitoring the stability of crosslinked protein crystals biotemplates: A feasibility study. Biotechnology and Bioengineering. 94, 1005-1011. Pubmed

Invited reviews

Lagziel-Simis, S., Cohen-Hadar, N., Moscovich-Dagan, H., Wine, Y. and Freeman, A. (2006). Protein-mediated nanoscale biotemplating. Current opinion in biotechnology. 17, 569-573. Pubmed


Wine, Y., Ippolito, G.C., Horton, A.P., Georgiou, G. (2015). Serology in the 21st century: the molecular-level analysis of the serum antibody repertoire. Current Opinion in Immunology. 35: 89-97. Pubmed


Conference proceeding

Wine, Y., Cohen-Hadar, N.,Lagziel-Simis, S.,  Dror Y., Felix Frolow, F. and Freeman, A. (2010). Adjustment of Protein Crystal Porosity for Biotemplating: Chemical and Protein Engineering Tools. AIP conference Proceedings. 76: 198-203. Ebsco host



Jason Lavinder, Yariv WINE, Danny Boutz, Edward Marcotte, George Georgiou. (2014). Proteomic identification of antibodies. Patent application PCT/US2012/066454


Crystal structures

  • Crystal structure analysis of the K171A mutation of N-terminal type II cohesin 1 from the cellulosomal ScaB subunit of Acetivibrio cellulolyticus. PDB ID: 2F2L

  • Parent Structure of Hen Egg White Lysozyme grown in acidic pH 4.8. Refinement for comparison with crosslinked molecules of lysozyme. PDB ID: 2HU3

  • Structure of Hen Egg-White Lysozyme Determined from crystals grown in pH 7.5. PDB ID: 2HUB

  • Crystal Structure Analysis of Hen Egg White Lysozyme Crosslinked by Polymerized Glutaraldehyde in Acidic Environment. PDB ID: 2HTX

  • Crystal structure Analysis of Hen Egg White Lyszoyme. PDB ID: 2HU1

bottom of page